Using PDE inhibitors to harness the benefits of calorie restriction: lessons from resveratrol
نویسنده
چکیده
In conclusion, the discovery of the resveratrol-PDE link suggests that PDE4 inhibitors, possibly in combination with other PDE inhibitors, may be useful for mimicking CR and for treating aging-related diseases.
منابع مشابه
Metabolic benefits of inhibiting cAMP-PDEs with resveratrol
Calorie restriction (CR) extends lifespan in species ranging from yeast to mammals. There is evidence that CR also protects against aging-related diseases in non-human primates. This has led to an intense interest in the development of CR-mimetics to harness the beneficial effects of CR to treat aging-related diseases. One CR-mimetic that has received a great deal of attention is resveratrol. R...
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